PAK4-IN-5

SKU: orb2802545

Description

PAK4-IN-5 (Compound 12i) is a potent and selective PAK4 inhibitor (IC50 = 7.68 nM) that blocks MDA-MB-231 cell proliferation and migration in vitro by suppressing PAK4/LIMK1 signaling. It induces G0/G1 arrest, apoptosis, and ROS production. The compound demonstrates an oral LD50 >500 mg/kg in mice, supporting its use in cancer research, particularly for studying PAK4's role in tumor progression.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• MW: 522.04
• Formula: C₃₁H₂₈ClN₅O
• SMILES: O=C(NC1=CC=CC(Cl)=C1)C(C=C2)=CC=C2C(N3)=NC(C3=C4)=CC=C4C5=CC=C(N6CCN(C)CC6)C=C5
• Target: Apoptosis,PAK,Reactive Oxygen Species

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176419323