PACMA 31

SKU: orb1303129

Description

PACMA 31 is a potent, irreversible covalent inhibitor of protein disulfide isomerase (PDI), exhibiting an IC50 of 10 µM. It demonstrates significant anti-tumor efficacy in ovarian cancer models, effectively suppressing tumor growth in vivo while showing a favorable targeting profile.

Key Properties

• CAS Number: 1401089-31-3
• MW: 430.47
• Purity: 99.92% (May vary between batches)
• Formula: C₂₁H₂₂N₂O₆S
• SMILES: CCOC(=O)CNC(=O)C(N(C(=O)C#C)c1ccc(OC)cc1OC)c1cccs1
• Target: Others
• Solubility: DMSO:100 mg/mL (232.3 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.29 mM)

Bioactivity

• In Vivo:
  In human ovarian cancer mouse xenografts, PACMA 31 (20-200 mg/kg) i.p. or per os administration of significantly inhibited tumor growth by 85% and 65% at day 62, respectively.
  Read more...
• In Vitro:
  In OVCAR-8 cells, PACMA 31 (0-10 μM) potently inhibits colony formation in a dose-dependent manner.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

protein disulfide isomerase (PDI), toxicity, tumor, Inhibitor, inhibit, oral, ovarian, PACMA 31, PACMA31, PACMA-31, mice, athymic, bond, covalent, colony

Compound Identifiers

PubChem CID

66555902