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PA36-2

SKU: orb3210246

Description

PA36-2 is an Mdr1 inhibitor and an azole resistance reversal agent, exhibiting an IC50 of 1.0 μg/mL and a Kd of 4.209 μM against Candida albicans Mdr1. By effectively inhibiting the activity of the Mdr1 efflux pump, PA36-2 prevents the expulsion of substrates from cells, thereby enhancing the intracellular accumulation of azole antibiotics. This compound can act synergistically with antifungals such as Fluconazole (FLC) and is useful for research on azole-resistant candidiasis.

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Key Properties

TargetAntifungal,P-gp

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information