p53-MDM2-IN-1

SKU: orb1737468

Description

p53-MDM2-IN-1 (Example 30) is a small molecule inhibitor of the p53-MDM2/X interaction with a Ki of 23.35 µM. It serves as a useful research tool for studying p53 pathway reactivation in cancer biology, applicable in both in vitro and in vivo anti-tumor research models.

Research Area

Cancer Biology; Cell Biology, Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 381717-91-5
• MW: 421.88
• Purity: 98.30% (May vary between batches)
• Formula: C₂₃H₂₀ClN₃O₃
• SMILES: C(=O)(C=1C(N(CCCN2C=CN=C2)C(=O)C1O)C3=CC=C(Cl)C=C3)C4=CC=CC=C4
• Target: p53,E1/E2/E3 Enzyme,MDM-2/p53,Mdm2
• Solubility: DMSO:Slightly soluble

Bioactivity

• Target IC50:
  p53-MDM2/X protein:23.35 µM(Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mdm2, p53, p53MDM2IN1, p53-MDM2-IN-1

Compound Identifiers

PubChem CID

2890999