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p53 DUBTAC modulator-1

SKU: orb3174693

Description

p53 DUBTAC modulator-1 (Compound A1) is a modulator of the p53 Y220C DUBTAC (Kd = 12.09 µM). It effectively reactivates mutant p53 Y220C and promotes its deubiquitination. This compound upregulates p53 Y220C protein levels, induces apoptosis, reduces Bcl-2 levels, and inhibits the Wnt signaling pathway. Additionally, p53 DUBTAC modulator-1 exhibits anticancer activity against liver cancer.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

TargetMDM-2/p53,Apoptosis,Wnt/beta-catenin,Bcl-2 Family

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information