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p53 Activator 17

SKU: orb3174434

Description

p53 Activator 17 is an activator of p53-Y220C. It exhibits selective cytotoxicity and pro-apoptotic (apoptosis) activity in cancer cell lines with the p53-Y220C mutation, with minimal effects on wild-type or p53-null cells. This compound promotes the conversion of intracellular p53-Y220C from a mutant to a wild-type conformation, activating the transcription of classic p53 target genes, including BBC3 (PUMA) and MDM2. p53 Activator 17 is applicable for research on hepatocellular carcinoma and breast cancer.

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Key Properties

TargetMDM-2/p53,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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p53 Activator 17 (orb3174434)

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