p38 kinase-IN-8

SKU: orb3218227

Description

2-(4-Fluorophenyl)-3-(4-pyridinyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine is a potent small-molecule inhibitor targeting mitogen-activated protein kinase 14 (p38α MAPK). It effectively inhibits kinase activity and human peripheral blood mononuclear cell function, exhibiting significant anti-inflammatory and immunomodulatory effects. Due to its critical role in regulating inflammatory pathways, it is widely studied for the treatment of various diseases including cancer, psoriasis, asthma, Crohn's disease, and neurodegenerative disorders.

Key Properties

• CAS Number: 401815-92-7
• MW: 357.30
• Formula: C₁₉H₁₁F₄N₃
• SMILES: FC=1C=CC(=CC1)C2=NN3C=C(C=CC3=C2C=4C=CN=CC4)C(F)(F)F
• Target: p38 MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

p38 MAPK