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p38α-IN-10

SKU: orb3175183

Description

p38α-IN-10 (Compound 8) is an orally active inhibitor of p38α, with an IC50 value of 230 nM. It effectively suppresses TNF production induced by LPS. p38α-IN-10 is applicable in the study of disorders such as rheumatoid arthritis and septic shock.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number180869-29-8
MW339.37
FormulaC18H18FN5O
SMILESFC1=CC=C(C=C1)C=2N=CN(C2C=3N=C(N=CC3)N)C4CCOCC4
TargetTNF,p38 MAPK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information