P2X7 receptor antagonist-4

SKU: orb1943186

Description

Compound 14a (P2X7 receptor antagonist-4) is a potent small molecule antagonist of the P2X7 receptor, demonstrating IC50 values of 64.7 nM (human) and 10.1 nM (mouse). It effectively suppresses NLRP3 inflammasome activation, reducing downstream pro-inflammatory mediators like caspase-1, GSDMD, IL-1β, and IL-18, as evidenced in murine models of sepsis-induced kidney injury. This compound is a valuable research tool for studying P27X7-mediated inflammation in both in vitro and in vivo contexts.

Research Area

Pharmacology & Drug Discovery

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Target	Others

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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