P2X7 receptor antagonist-4

SKU: orb1943186

Description

Compound 14a (P2X7 receptor antagonist-4) is a potent small molecule antagonist of the P2X7 receptor, demonstrating IC50 values of 64.7 nM (human) and 10.1 nM (mouse). It effectively suppresses NLRP3 inflammasome activation, reducing downstream pro-inflammatory mediators like caspase-1, GSDMD, IL-1β, and IL-18, as evidenced in murine models of sepsis-induced kidney injury. This compound is a valuable research tool for studying P27X7-mediated inflammation in both in vitro and in vivo contexts.

Research Area

Pharmacology & Drug Discovery

Key Properties

• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others