P140

SKU: orb1821034

Description

P140 is a peptide from the small nuclear ribonucleoprotein U1-70K, phosphorylated at the Ser140 position. P140 binds to the HSPA8/HSC70 chaperone protein, a constitutively expressed, cognate protein of the HSP70 family, which is involved in many cellular processes and has a key regulatory role in autophagy. Both in vitro and in vivo, P140 interferes with hyperactivated chaperone-mediated autophagy, modifying overexpression of major histocompatibility complex class II molecules and antigen presentation to autoreactive T cells. In a lupus prone murine model, P140 displays tolerogenic and immunomodulatory effects, depleting hyperactivated autoreactive T and B cells and restoring normal immune homeostasis. P140 decreases proteinuria and anti-DNA antibody production, and significantly prolongs survival.

Key Properties

• CAS Number: 497156-60-2
• MW: 2638.94 Da
• Purity: >95% by hplc
• Formula: C₁₁₇H₁₈₁N₃₂O₃₂PS
• Protein Sequence: H-Arg-Ile-His-Met-Val-Tyr-Ser-Lys-Arg-Ser-(PO3)-Gly-Lys-Pro-Arg-Gly-Tyr-Ala-Phe-Ile-Glu-Tyr-OH

Storage & Handling

• Storage: Store dry, frozen and in the dark
• Form/Appearance: Freeze dried solid
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phosphopeptide P140, CEP 33457, Forigerimod, IPP 201101