P110δ-IN-1

SKU: orb1307917

Description

P110δ-IN-1 (PWT-143) is a potent and selective small molecule inhibitor of the PI3K delta isoform, demonstrating an IC50 of 8.4 nM. This compound is a valuable research tool for studying B-cell signaling and immunology, with applications in both in vitro cellular assays and in vivo disease models for autoimmune disorders and hematological cancers.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1595129-71-7
• MW: 604.77
• Purity: 99.95% (May vary between batches)
• Formula: C₃₁H₄₀N₈O₃S
• SMILES: CN1CCC(CC1)c1ccccc1CC(C)(C)Nc1nc(nc(n1)-n1c(nc2ccccc12)S(C)(=O)=O)N1CCOCC1
• Target: PI3K
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.65 mM);DMSO:5 mg/mL (8.27 mM)

Bioactivity

• Target IC50:
  p110δ:0.6 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Phosphoinositide 3-kinase, PI3K, PWT143, PWT-143, PWT 143, p110δ, P110δ IN 1, P110δIN1, P-110δ-IN-1, P110δ-IN-1, P110delta-IN-1

Compound Identifiers

PubChem CID

73441802