p-Hydroxycinnamic acid

SKU: orb1300108

Description

p-Hydroxycinnamic acid is a bioactive compound that inhibits platelet activity. It demonstrates inhibitory effects on thromboxane B2 and LPS-induced prostaglandin E2 production with IC50 values of 371 μM and 126 μM, respectively. This small molecule is used in research on inflammation, thrombosis, and eicosanoid signaling pathways in vitro.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 7400-08-0
• MW: 164.16
• Purity: 99.83% (May vary between batches)
• Formula: C₉H₈O₃
• SMILES: C(=CC(O)=O)C1=CC=C(O)C=C1
• Target: Endogenous Metabolite,Prostaglandin Receptor,Thrombin
• Solubility: DMSO:6.25 mg/mL (38.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.09 mM)

Bioactivity

• Target IC50:
  Prostaglandin E2:126 μM|TXB2:371 μM
• In Vitro:
  p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55 2 (SE 4 01) % and 35 6 (SE 2 35) % relative to the basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary hemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, p-Cumaric acid, p-Coumaric acid, NSC-59260, NSC59260, inhibit, Inhibitor, NSC 59260, ProstaglandinReceptor, Prostaglandin Receptor, pHydroxycinnamic acid, p-Hydroxycinnamic acid, p-Hydroxy-cinnamic acid, Thromboxane A2 synthetase, PGE2, p Hydroxycinnamic acid

Compound Identifiers

PubChem CID

322