P-gp modulator-7

SKU: orb3027658

Description

P-gp modulator-7 (Compound 9e) is an inhibitor of P-glycoprotein (P-gp). It uniquely occupies the channel entrance of P-gp in a T-shaped conformation, blocking the peristaltic extrusion mechanism of transmembrane domains TM12 and TM9. This action inhibits P-gp from pumping drugs out of cells and reverses multidrug resistance (MDR) in tumor cells. P-gp modulator-7 shows promise for cancer research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• Formula: C₃₆H₆₀N₂O₅
• Target: P-gp

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

P-gp