P-gp-IN-32

SKU: orb3173049

Description

P-gp-IN-32 is a P-glycoprotein (P-gp) inhibitor with low cytotoxicity, demonstrating significant multidrug resistance (MDR) reversal activity against doxorubicin in MCF7/ADR cells. It has an IC50 value of 0.11 μM and a resistance reversal factor (RF) of 215.9. P-gp-IN-32 interacts directly with P-gp, inducing conformational changes and inhibiting its efflux function. This compound is applicable in cancer research, including studies on breast cancer.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2918249-59-7
• MW: 562.67
• Formula: C₃₅H₃₄N₂O₅
• SMILES: O=C(C1=CC2=CC(=CC=C2N1CC3=CC=C(OC)C=C3)C=4C=CC=C(OC)C4)N5CC6=CC(OC)=C(OC)C=C6CC5
• Target: P-gp

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

P-gp