Oxythiamine

SKU: orb1708948

Description

Oxythiamine is a thiamine antivitamin and transketolase inhibitor that suppresses cancer cell proliferation by blocking non-oxidative ribose synthesis. It induces cell cycle arrest and apoptosis, demonstrating potential anticancer activity in both in vitro and in vivo research models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 136-16-3
• MW: 266.34
• Purity: 99.91% (May vary between batches)
• Formula: C₁₂H₁₆N₃O₂S
• SMILES: O=C1NC(=NC=C1C[N+]2=CSC(=C2C)CCO)C
• Target: Transketolase,Apoptosis,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.51 mM);DMSO:40 mg/mL (150.18 mM)

Bioactivity

• Target IC50:
  MIAPaCa2 cells:14.95 μM
• In Vivo:
  s.c. injection C57BL/6 mice with LLC cells and supplemented the mice with a low- or a high-dose of Oxythiamine (250 or 500 mg/kg BW) daily for 5 wk. During the 5-wk period, Oxythiamine supplementation decreased plasma MMP-2 activity in a dose-dependent manner, and this effect was significant after 4 wk of tumor cell implantation.
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• In Vitro:
  Oxythiamine for MIA PaCa-2 cells 5-320 μM for 2 days IC50 is 14.95 μM MTT, MIA PaCa-2 cells concentrations of Oxythiamine (0 μM, 5 μM, 50 μM and 500 μM) for 48 hours two-dimensional gel electrophoresis (2DE). Oxythiamine altered protein expression in a dose dependent manner. The MIC and MFC values of Oxythiamine were in the range 0.08 × 103 to 10 × 103 mg/L. A549 cells were co-cultured with Oxythiamine (from 0.1 to 100 μM) for 6–12 h CCK-8 assay Oxythiamine contributes to a significant reduction of A549 cell viability of 11.7%, 23.6%, and 28.2% at 12, 24, and 48 h. Oxythiamine arrests the cell growth in G1 phase of cell cycle. Oxythiamine inhibits the growth of A549 cells by initially slowing-down cell cycle and by leading to apoptosis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Hydroxythiamin, Thiamine, Oxythiamine, TK

Compound Identifiers

PubChem CID

8682