Oxytetracycline

SKU: orb1310191

Description

Oxytetracycline is a tetracycline-class antibiotic derived from Streptomyces rimosus. It is widely used in research for its antibacterial properties in both in vitro assays and in vivo infection models, studying mechanisms of action and bacterial resistance.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 79-57-2
• MW: 460.43
• Purity: 99.11% (May vary between batches)
• Formula: C₂₂H₂₄N₂O₉
• SMILES: [H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
• Target: Endogenous Metabolite,Antibiotic,Antibacterial,ribosome,HSV
• Solubility: DMSO:90 mg/mL (195.47 mM);Ethanol:10 mg/mL (21.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.17 mM)

Bioactivity

• In Vivo:
  Oxytetracycline (200 mg/kg for 15 days) results a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in rat liver. Oxytetracycline also causes a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in rat liver. Oxytetracycline (200 mg/kg) combined with Naringenin (50 mg/kg b.w.t.) significantly decreases the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the rat liver. Oxytetracycline (200 mg/kg, oral for 15 days) produces hepatic damage as manifested by a significant increase in serum hepatic markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and increases plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide) in rats. Oxytetracycline significantly decreases the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

30S ribosome, 16S ribosome, Antibiotic, aminoacil-tRNA, Bacterial, Inhibitor, Herpes simplex virus, EndogenousMetabolite, Endogenous Metabolite, Gram-positive, Gram-negative, HSV-1, HSV, inhibit, m-ribosomal, Oxytetracycline, tetracycline, Terramycin, synthesis, protein

Compound Identifiers

PubChem CID

54675779