(-)-Oxypeucedanin hydrate

SKU: orb1301472

Description

(-)-Oxypeucedanin hydrate is a naturally occurring furanocoumarin metabolite. It is utilized in biochemical research, with studies investigating its biological activities in both in vitro assays and in vivo models to explore its potential pharmacological properties.

Key Properties

• CAS Number: 133164-11-1
• MW: 304.29
• Purity: 98.00% (May vary between batches)
• Formula: C₁₆H₁₆O₆
• SMILES: CC(C)(O)[C@@H](O)COc1c2ccoc2cc2oc(=O)ccc12
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.57 mM);DMSO:55 mg/mL (180.75 mM)

Bioactivity

• In Vitro:
  Oxypeucedanin exhibited marginal toxicity on normal fibroblast cells and sensitive parental mouse lymphoma cells; furthermore, they were less toxic on multidrug resistant lymphoma cells. Oxypeucedanin showed moderate MDR reversing activity. In the checkerboard assay, oxypeucedanin and heraclenin showed slight synergistic effect with doxorubicin. These compounds might improve the cytotoxic effect of the standard chemotherapeutic drug doxorubicin.
• Cell Research:
  Pure compounds were isolated from the extract of aerial parts of the plant by chromatographic methods.Bioactivities were tested on multidrug resistant and sensitive mouse T-lymphoma cell lines.The inhibition of the cancer MDR efflux pump ABCB1 was evaluated by flow cytometry (at 2 and 20 μM).A checkerboard microplate method was applied to study the interactions of furocoumarins and doxorubicin.Toxicity was studied using normal murine NIH/3T3 fibroblasts.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cytotoxic, cell, ()Oxypeucedanin hydrate, ( ) Oxypeucedanin hydrate, antiproliferative, cancer, inhibit, Inhibitor, tumor, Oxypeucedanin Hydrate, OXYPEUCEDANIN HYDRATE

Compound Identifiers

PubChem CID

899657