Oxybenzone

SKU: orb1310553

Description

Oxybenzone

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 131-57-7
• MW: 228.2433
• Purity: 99.97% (May vary between batches)
• Formula: C₁₄H₁₂O₃
• SMILES: COC1=CC=C(C(=O)C2=CC=CC=C2)C(O)=C1
• Target: Autophagy,Apoptosis,Retinoid Receptor
• Solubility: DMSO:50 mg/mL (219.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.76 mM)

Bioactivity

• In Vivo:
  In mice studies, oxybenzone(BP-3) exposure significantly affects fecundity, as well as inducing unexplained mortality in lactating mothers. Studies in both mice and rats demonstrate that generational exposure to oxybenzone(BP-3) reduces body weight, increases liver ([50 %) and kidney weights, induces a 30 % increase in prostate weight, a reduction in immunocompetence, and significantly increases uterine weight in juveniles. In mammals, oxybenzone(BP-3) is renowned for having estrogenic and anti-androgenic activities, causing activation of estrogen receptor proteins and inhibition of androgen receptors.
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• In Vitro:
  A dose-dependent inhibition of PGE2-production is found in the HEPM cell culture following oxybenzone exposure. Benzophenones, including oxybenzone(BP-3) are documented mutagens that increase the rate of damage to DNA, especially when exposed to sunlight. It either can act directly as genotoxicants or become genotoxicants by bioactivation via cytochrome P450 enzymes. Oxybenzone can generate reactive oxygen species, which are potential mutagens, when applied topically to the skin followed by UV light exposure.
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• Cell Research:
  Cells are grown at 37℃ with 100% humidity and 10% CO2. Prior to analyses, cells are subcultured onto 24-well plates and allowed to become 70-90% confluent. On day 1 of the experiment, cells are washed three times with serum-free media containing 0.5% bovine serum albumin (BSA), followed by replacement with the same media that also contained 1 ng/ml of IL-1β with or without oxybenzone. After an exposure time of 24 h, the media are removed, the pH adjusted to 3.5 with HCl, and finally assayed for PGE2-production. (Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

neuronal, KAHSCREEN BZ-3, inhibit, Inhibitor, filter, Eusolex 4360, Escalol 567, cells, Benzophenone3, Benzophenone-3, Benzophenone 3, Apoptosis, Autophagy, blood-brain, barriers, sun, Retinoid Receptor, Retinoic acid receptors, RetinoidReceptor, Retinoid X receptors, placental, RAR/RXR, Oxybenzone

Compound Identifiers

PubChem CID

4632