Oxotremorine sesquifumarate

SKU: orb1305721

Description

Oxotremorine sesquifumarate

Research Area

Neuroscience

Key Properties

• CAS Number: 17360-35-9
• MW: 380.39
• Purity: 97.94% (May vary between batches)
• Formula: C₁₂H₁₈N₂O·3/2C₄H₄O₄
• SMILES: OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.O=C1CCCN1CC#CCN1CCCC1.O=C1CCCN1CC#CCN1CCCC1
• Target: AChR
• Solubility: H2O:< 8 mg/mL (21.03 mM);DMSO:55 mg/mL (144.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM)

Bioactivity

• In Vivo:
  Rats with signs of neuropathy were subjected to SCS applied in awake, freely moving condition. Oxotremorine was administered intrathecally. Tactile, cold and heat sensitivities were assessed by using von Frey filaments, cold spray and focused radiant heat, respectively. Oxotremorine i.t. dose-dependently suppressed the tactile hypersensitivity. SCS markedly increased withdrawal thresholds (WTs), withdrawal latencies and cold scores.
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• In Vitro:
  Oxotremorine (10.5 micron) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mAChR, neurological, Muscarinic acetylcholine receptor, inhibit, Inhibitor, Oxotremorine sesquifumarate, tremorogenic

Compound Identifiers

PubChem CID

6436473