Oxfendazole

SKU: orb1310358

Description

Oxfendazole (RS-8858) is a benzimidazole anthelmintic effective against nematodes including roundworms, strongyles, and pinworms. It is widely used in veterinary research and has been employed in both in vivo animal studies and in vitro mechanistic investigations of parasite tubulin inhibition.

Research Area

Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 53716-50-0
• MW: 315.35
• Purity: 99.17% (May vary between batches)
• Formula: C₁₅H₁₃N₃O₃S
• SMILES: S(=O)(C=1C=C2C(N=C(NC(OC)=O)N2)=CC1)C3=CC=CC=C3
• Target: Glucokinase,Parasite,Microtubule Associated
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:28.7 mg/mL (91.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.34 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Oxfendazole (OX) induces not only mRNA expression of phase I enzymes Cyp1a1, Cyp1a2, but also Nrf2-regulated phase II enzymes such as Gpx2, Nqo1, Yc2, Akr7a3 and Gstm1 in rats, presumably due to an adaptive response against OX-induced oxidative stress. Oxfendazole enhances oxidative DNA damage (as assessed by 8-hydroxydeoxyguanosine; 8-OHdG) and lipid peroxidation (as assessed by thiobarbituric acid-reactive substances; TBARS) in rats. Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increase 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and more particularly the isoenzyme P450IA2 (95% and 184% increases) in rabbit liver. Oxfendazole MRL induces a mutagenic effect in all tested cell types. Oxfendazole exhibits embryotoxicity including teratogenicity. Oxfendazole induces a disturbance in the different biochemical contents of all tested tissues in mice. Oxfendazole increases the incidence and multiplicity of altered foci (4.0- and 3.6-fold, respectively) and hepatocellular adenomas (HCAs) (3.0- and 5.5-fold, respectively). Oxfendazole treatment induces 5.2- and 5.6-fold increases in the number of proliferating cell nuclear antigen (PCNA)-positive cells and single-stranded DNA (ssDNA)-positive cells in HCAs compared with the surrounding tissue, respectively. Oxfendazole and its sulphone metabolite attain a significantly higher plasma concentration and remain much longer in plasma compared with fenbendazole (FBZ) and albendazole (ABZ) and their respective metabolites in dogs.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glucose uptake inhibitor, Parasite, Microtubule Associated, MicrotubuleAssociated, Inhibitor, inhibit, RS8858, RS-8858, RS 8858, Oxfendazole, Tubulin chain

Compound Identifiers

PubChem CID

40854