OVA Peptide (323-339)

SKU: orb2278952

Description

OVA Peptide (323-339) is the immunodominant T-cell epitope from chicken ovalbumin, binding H2-IAd and acting as a B-cell epitope for IgE. It is a key tool for modeling egg allergy, inducing Th2 responses and IgE production in murine in vivo studies of hypersensitivity.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 92915-79-2
• MW: 1773.9
• Purity: 99.38% (May vary between batches)
• Formula: C₇₄H₁₂₀N₂₆O₂₅
• SMILES: [C@@H](CC1=CN=CN1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CO)=O)CCC(N)=O)=O)C)=O)[C@H](C)C)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCNC(=N)N)C(O)=O)=O)=O)C)=O)CCC(O)=O)=O)CC(N)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)C)=O)=O)C)=O)C)=O
• Target: MHC
• Solubility: H2O:10 mg/mL (5.64 mM)

Bioactivity

• In Vivo:
  OVA Peptide (323-339) is widely used in BALB/c mouse models to induce allergic immune responses. Repeated exposure results in enhanced production of OVA-specific IgE and Th2 cytokines, making it a potent tool for modeling antigen-specific hypersensitivity and allergy-related immune activation .
• In Vitro:
  At low concentrations (0.01 μM), OVA Peptide (323-339) enhances the ability of M2Y-type B cells to activate Th cells, more so than M2-type B cells.

Storage & Handling

• Storage: keep away from moisture | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

16201090