OTSSP167

SKU: orb1307517

Description

OTSSP167

Research Area

Signal Transduction

Key Properties

• CAS Number: 1431697-89-0
• MW: 487.42
• Purity: 98.90%
• Formula: C₂₅H₂₈Cl₂N₄O₂
• SMILES: CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O
• Target: MELK
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:7.22 mg/mL (14.81 mM)

Bioactivity

• Target IC50:
  MELK:0.41 nM
• In Vivo:
  OTSSP167 inhibited the phosphorylation of PSMA1 and DBNL, novel MELK substrates that are essential for stem cell characterization and invasiveness.OTSSP167 inhibited sphere formation in breast cancer cells by inhibiting PSMA1 phosphorylation.OTSSP167 inhibited high levels of MELK expression in A549, T47D, DU4475 and 22Rv1 cancer cells with IC50 of 6.7, 4.3, 2.3 and 6.0 nM, respectively.
• In Vitro:
  OTSSP167 inhibited the phosphorylation of PSMA1 and DBNL, novel MELK substrates that are essential for stem cell characterization and invasiveness.OTSSP167 inhibited sphere formation in breast cancer cells by inhibiting PSMA1 phosphorylation.OTSSP167 inhibited high levels of MELK expression in A549, T47D, DU4475 and 22Rv1 cancer cells with IC50 of 6.7, 4.3, 2.3 and 6.0 nM, respectively.
• Cell Research:
  Cell Counting Kit-8(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Maternal embryonic leucine zipper kinase, MELK, MELK inhibitor, OTS 167, OTS167, OTS-167, OTSSP 167, OTSSP167, OTSSP-167

Compound Identifiers

PubChem CID

135398499