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OTS514

SKU: orb1690021

Description

OTS514 hydrochloride is a potent and selective TOPK inhibitor with nanomolar IC50 values against small cell lung cancer (SCLC) cell lines. It suppresses tumor growth by inhibiting FOXM1 activity and demonstrates enhanced cytotoxicity against CD90-positive and sphere-derived cancer stem-like cells in vitro.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1338540-63-8
MW364.46
Purity99.62% (May vary between batches)
FormulaC21H20N2O2S
SMILESC[C@@H](CN)c1ccc(cc1)-c1c(O)cc(C)c2[nH]c(=O)c3sccc3c12
TargetApoptosis,TOPK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.05 mM);DMSO:90 mg/mL (246.94 mM)

Bioactivity

Target IC50
TOPK:2.6 nM (IC50)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TOPK, positive, Inhibitor, HMCL, OTS 514, OTS 514 Hydrochloride, OTS514 Hydrochloride, OTS-514 Hydrochloride, OTS514, OTS-514, OTS514 HCl, myeloma, multiple, inhibit, cell, cycle, Apoptosis, arrest, cancer

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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200 mg
100 mg
1 mg
$ 110.00
5 mg
$ 200.00
1 ml x 10 mM (in DMSO)
$ 210.00