OTS186935 FA

SKU: orb1962285

Description

OTS186935 FA is a selective SUV39H2 methyltransferase inhibitor used in epigenetic and cancer research. It demonstrates antitumor activity by inhibiting proliferation in breast (MDA-MB-231) and lung (A549) carcinoma cell lines in vitro.

Research Area

Epigenetics & Chromatin

Key Properties

• MW: 509.98
• Purity: 99.52% (May vary between batches)
• Formula: C₂₆H₂₈ClN₅O₄
• SMILES: COC1=C(C2=CN(C=CC(N3C[C@H](CC3)NCC4=CC=NC=C4)=C5)C5=N2)C=C(C(OC)=C1)Cl.[H]C(O)=O
• Target: Histone Methyltransferase

Bioactivity

• Target IC50:
  A549 cells:0.67μM
• In Vivo:
  Immunocompromised mice carrying MDA-MB-231 were intravenously administered with OTS186935 or vehicle control at a dose of 10 mg/kg once daily for 14 days. On the 14th day, a tumor growth inhibition (TGI) of 42.6% was observed.
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• In Vitro:
  OTS186935 FA that showed enzymatic IC50 of 6.49 nM and A549 cell growth inhibitory effect with IC50 of 0.67 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

OTS186935 FA(2093400-18-9 Free base), OTS186935FA(2093400189Freebase), Histone Methyltransferase, HistoneMethyltransferase, SUV39H2

Compound Identifiers

PubChem CID

171360065