Oteseconazole

SKU: orb1307922

Description

Oteseconazole (VT-1161) is an orally bioavailable antifungal agent that selectively and potently inhibits Candida albicans CYP51 (Kd <39 nM) without significantly affecting the human ortholog. It is a valuable research tool for studying fungal pathogenesis and has demonstrated efficacy in both in vitro assays and in vivo models of candidiasis.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 1340593-59-0
• MW: 527.39
• Purity: 99.95%
• Formula: C₂₃H₁₆F₇N₅O₂
• SMILES: O[C@@](Cn1cnnn1)(c1ccc(F)cc1F)C(F)(F)c1ccc(cn1)-c1ccc(OCC(F)(F)F)cc1
• Target: Antifungal,Cytochromes P450
• Solubility: DMSO:250 mg/mL (474.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.48 mM)

Bioactivity

• Target IC50:
  CYP2C19:72 μM|CYP2C9:99 μM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VT1161, VT-1161, VT 1161, inhibit, Oteseconazole, Fungal, Inhibitor, Cytochrome P450, CYP51, CYPs, antifungal

Compound Identifiers

PubChem CID

77050711