Otenzepad

SKU: orb1307923

Description

Otenzepad (AF-DX 116) is a selective M2 muscarinic acetylcholine receptor antagonist, exhibiting IC50 values of 386 nM in rat heart and 640 nM in rabbit peripheral lung. This compound is widely used in pharmacological research to investigate cholinergic signaling in both in vitro binding assays and in vivo cardiovascular studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 102394-31-0
• MW: 421.54
• Purity: 99.81%
• Formula: C₂₄H₃₁N₅O₂
• SMILES: CCN(CC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
• Target: AChR
• Solubility: DMSO:24 mg/mL (56.93 mM)

Bioactivity

• Target IC50:
  M2 mAChR (rat heart):386 nM|M2 mAChR (rabbit peripheral lung):640 nM
• In Vivo:
  In rats, Otenzepad (2 mg/kg; s.c.) significantly improved retention relative to vehicle controls. Otenzepad (0.5, 1 mg/kg; s.c.) significantly improved win-stay acquisition. In mice, Otenzepad (0.3, 1.0, or 3.0 mg/kg, i.p.) reverses the effects of insulin on memory and potentiates the effects of glucose.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AF-DX 116, AF-DX116, AF-DX-116, memory, mAChR, M2 mAChR, M2 muscarinic acetylcholine receptor in rabbit peripheral lung, Otenzepad, inhibit, Muscarinic acetylcholine receptor, Inhibitor

Compound Identifiers

PubChem CID

107867