Otenabant hydrochloride

SKU: orb1307424

Description

Otenabant hydrochloride

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 686347-12-6
• MW: 546.88
• Purity: 99.79%
• Formula: C₂₅H₂₆Cl₃N₇O
• SMILES: Cl.CCNC1(CCN(CC1)c1ncnc2n(c(nc12)-c1ccccc1Cl)-c1ccc(Cl)cc1)C(N)=O
• Target: Cannabinoid Receptor
• Solubility: DMSO:Slightly soluble

Bioactivity

• Target IC50:
  CB1 (human):0.7 nM(Ki)|CB1 (rat):2.8 nM(Ki)
• In Vivo:
  CP-945598 HCl exhibits lower affinity towards human CB2 receptors (Ki: 7.6 μM) and demonstrates inhibitory effects o the CB1 receptor. Additionally, it possesses moderate microsomal clearance, low affinity for hERG, and sufficient penetration o the central nervous system (CNS).
• In Vitro:
  In a diet-induced obesity model in mice, CP-945598 (10 mg/kg) facilitated a 9% reduction in body weight over a 10-day weight loss study. CP-945598 significantly enhanced energy expenditure in rats and reduce the respiratory quotient, indicating a metabolic shift towards increased fat oxidation. Additionally, CP-945598 HCl reversed behaviors mediated by four cannabinoid agonists (hypothermia, spontaneous activity, catalepsy, and analgesia). In acute food intake models in rodent species, CP-945598 HCl suppressed appetite, further promoting fat oxidation and energy consumption.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Otenabant, Otenabant (CP-945598) HCl, Otenabant hydrochloride, Otenabant Hydrochloride, inhibit, hCB2, hCB1, Inhibitor, CP 945598, CP 945598 Hydrochloride, CP945598, CP-945598, CP945598 Hydrochloride, CP-945598 Hydrochloride, CB, Cannabinoid Receptor, CannabinoidReceptor, rCB1

Compound Identifiers

PubChem CID

16223963