OT-551 HCl

SKU: orb1745240

Description

OT-551 HCl is a disubstituted hydroxylamine and NF-κB inhibitor with antioxidant properties. It has been investigated in preclinical research for ocular diseases, including studies exploring its potential in models of cataracts, age-related macular degeneration, and geographic atrophy.

Research Area

Signal Transduction

Key Properties

• CAS Number: 627085-15-8
• MW: 277.79
• Purity: 99.71% (May vary between batches)
• Formula: C₁₃H₂₄ClNO₃
• SMILES: Cl.CC1(C)CC(CC(C)(C)N1O)OC(=O)C1CC1
• Target: NF-κB
• Solubility: DMSO:3.6 mg/mL (12.96 mM)

Bioactivity

• In Vivo:
  OT-551 HCl (intraperitoneally injected; rats; approximately 30 min prior to a 6 h exposure to 2700 lux white fluorescent light) significantly reduced the number of RPE cell nuclei in light-exposed eyes from water-treated animals. RPE damage index was significantly lower in the animals treated with any dose of OT-551 HCl compared to water-treated animals both in the inferior and superior hemispheres. Systemic administration of OT-551 HCl provides RPE cell protection against acute light damage.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NF-κB, NFκB, NF-kB, NFkB, 627085-11-4 Free base, 627085-11-4, OT-551 HCl, OT-551 HCl(627085-11-4 Free base)

Compound Identifiers

PubChem CID

11482818