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OSU-T315

SKU: orb1226527

Description

A novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM; exhibits high in vitro potency against a panel of prostate and breast cancer cell lines (IC50=1-2.5 uM) with no effect on normal epithelial cells; facilitates the dephosphorylation of Akt at Ser-473 and other ILK targets, including GSK-3β and myosin light chain; suppresses the expression of the transcription/translation factor YB-1 and HER2, EGFR in PC-3 cells, induces autophagy and apoptosis; demonstrates in vivo efficacy in suppressing PC-3 xenograft tumor growth; orally active.

Images & Validation

Key Properties

CAS Number1333146-24-9
MW533.5873
Purity>98% (HPLC)
FormulaC30H30F3N5O
SMILESO=C(NC)CCC1=NN(C2=CC=C(N3CCNCC3)C=C2)C(C4=CC=C(C5=CC=C(C(F)(F)F)C=C5)C=C4)=C1
TargetIntegrin
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

OSU-T 315

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Quality Guarantee

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Protocol Information

Available Sizes

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200 mg
500 mg
2 mg
$ 170.00
5 mg
$ 270.00
10 mg
$ 350.00
25 mg
$ 440.00
50 mg
$ 540.00
100 mg
$ 770.00