OSU-ERβ-12

SKU: orb3174675

Description

OSU-ERβ-12 is a selective orally active ERβ agonist capable of crossing the blood-brain barrier, exhibiting an EC50 of 78.3 nM and a Ki of 2.02 nM. It demonstrates over 200-fold selectivity for ERβ over ERα. OSU-ERβ-12 binds strongly to ERβ and reduces the expression of TGF-β-mediated profibrotic genes, thereby aiding in the reduction of liver fibrosis. This compound is useful for studying fibrotic liver diseases, non-alcoholic fatty liver disease (NAFLD), and neuroinflammation.

Research Area

Metabolism Research

Key Properties

• Target: Estrogen Receptor/ERR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR