Ostarine

SKU: orb1745247

Description

Ostarine (MK-2866) is a selective androgen receptor modulator (SARM) that mimics testosterone's anabolic effects, promoting muscle growth and potentially counteracting muscle wasting. Its research applications include studies on cancer cachexia, with investigations conducted in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 841205-47-8
• MW: 389.33
• Purity: 99.90%
• Formula: C₁₉H₁₄F₃N₃O₃
• SMILES: C[C@@](O)(COc1ccc(cc1)C#N)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F
• Target: Androgen Receptor
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (141.27 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.14 mM);Ethanol:72 mg/mL (184.93 mM)

Bioactivity

• Target IC50:
  Androgen receptor:3.8 nM(Ki)
• In Vivo:
  Ostarine (10 nM) modulates the transcriptional activity of the androgen receptor (AR) in CV-1 cells co-transfected with human androgen receptor expression vectors, luciferase reporter vectors, and β-galactosidase control vectors. Ostarine binds to the androgen receptor with the highest affinity among selective androgen receptor modulators (SARMs), exhibiting a Ki value of 3.8 nM.
• In Vitro:
  Compared to any non-steroidal androgen receptor (AR) agonists, Ostarine exhibits the highest androgenic and anabolic activity in the body, particularly affecting the prostate, seminal vesicles, and levator ani muscle, with ED50 values of 0.12, 0.39, and 0.03 mg/day, respectively. This makes it four times more effective on the levator ani muscle than testosterone propionate. At a low dose of 0.03 mg/day, Ostarine demonstrates effective and selective activity in anabolic tissues. Following a single intravenous injection of 10 mg/kg, Ostarine presents a slow decline in plasma concentration with a longer half-life of 6 hours, compared to the 2.6-4.0 hours half-life when targeting other cyan/nitro substituted Selective Androgen Receptor Modulators (SARMs). In castrated male rats, Ostarine shows significant androgenic and anabolic activity, more effectively stimulating growth in the prostate, seminal vesicles, and levator ani muscle than other cyan/nitro substituted SARMs. Ostarine facilitated recovery of prostate weight by 39.2%, seminal vesicle weight by 78.8%, and notably stimulated levator ani muscle growth beyond other male organs to 141.9%.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ostarine, MK 2866, MK2866, MK-2866, Enobosarm, GTX024, GTX-024, GTX 024, AndrogenReceptor, Androgen Receptor

Compound Identifiers

PubChem CID

25226380