OSS-128167

SKU: orb1223743

Description

OSS-128167 is a novel selective, cell permeable SIRT6 inhibitor with IC50 of 89, 1578 and 751 uM for SIRT6, SIRT1 and SIRT2, respectively; increases H3K9 acetylation and GLUT-1 expression in treated cells.

Key Properties

• CAS Number: 887686-02-4
• MW: 366.329
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₄N₂O₆
• SMILES: C1=CC(NC(=O)C2=CC=CO2)=CC(C(=O)NC2=CC=C(O)C(C(O)=O)=C2)=C1
• Target: Sirtuin
• Solubility: DMSO: 68 mg/mL (185.6 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vivo:
  Animal model: Male HBV transgenic mice (6-8-week-old). Dosage: 50 mg/kg. Administration: Intraperitoneal injection; every 4 days; for 12 days. Result: The level of HBV DNA and 3.5-Kb RNA were markedly suppressed in HBV transgenic mice.
• In Vitro:
  Western blot analysis. Cell line: BxPC3 cells. Concentration: 100 μM. Incubation time: 0 hours, 2 hours, 6 hours, 18 hours, 24 hours. Result: Increased H3K9 acetylation. RT-PCR Cell line: HepG2.2.15 and HepG2-sodium taurocholate cotransporting polypeptide (NTCP) cells Concentration: 100 μM. Incubation time: 96 hours. Result: Significantly decreased HBV core DNA and 3.5-Kb RNA levels.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

OSS128167

Quick Database Links

Gene Symbol

Sirtuin