OSMI-3

SKU: orb1708967

Description

OSMI-3 is a cell-permeable, potent small molecule inhibitor of O-GlcNAc transferase (OGT). It is widely used in research to investigate the role of OGT and O-GlcNAcylation in cancer biology and cardiovascular disease models, both in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2260791-13-5
• MW: 669.77
• Purity: >99.99% (May vary between batches)
• Formula: C₃₂H₃₅N₃O₉S₂
• SMILES: [C@@H](C(N(CC1=CC=CS1)CC(OCC)=O)=O)(NS(=O)(=O)C=2C=C3C(=CC2)NC(=O)C=C3)C4=C(OCCCC(OCC)=O)C=CC=C4
• Target: Others,Acyltransferase,Transferase

Bioactivity

• In Vitro:
  Treatment with OSMI-3 (Compound 2b) at concentrations ranging from 20 to 50 μM for durations of 4 to 24 hours in HCT116 cells significantly decreases O-GlcNAc levels, demonstrating more sustained cellular effects compared to OSMI-2.In cells treated with OSMI-3 (Compound 2b), there is an observable decrease in HCF-1 cleavage products and an increase in uncleaved HCF-1. Given that OGT knockdown is known to reduce cell proliferation, the impact of OSMI-3 on cell growth over 96 hours is monitored. Although there is no evidence of apoptosis, a reduction in cell growth over time is evident, consistent with the results observed with OGT knockdown.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

O-GlcNAc transferase (OGT), OSMI 3, OSMI3, OSMI-3

Compound Identifiers

PubChem CID

146014495