ORM-10921

SKU: orb1699744

Description

ORM-10921 is a selective α2C-adrenoceptor antagonist. Preclinical studies in animal models have demonstrated its potential for treating psychiatric disorders, showing both antipsychotic and antidepressant-like effects. This compound is used in neuroscience research to investigate receptor function in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 610782-82-6
• MW: 285.38
• Purity: 99.98% (May vary between batches)
• Formula: C₁₈H₂₃NO₂
• SMILES: C(OC)[C@]1(C)[C@]2(C3=C(C=4C(O3)=CC=CC4)CCN2CCC1)[H]
• Target: Adrenergic Receptor
• Solubility: DMSO:45 mg/mL (157.68 mM)

Bioactivity

• Target IC50:
  α2C-adrenoceptor:1.4 nM (Ki)
• In Vivo:
  The role of the α2C-AR in modulating two key depression-related behaviors in the Flinders Sensitive Line (FSL) rat was studied using a dose-response analysis following subcutaneous administration with the selective α2C-AR antagonist ORM-10921 (0.03, 0.3 mg/kg), the nonselective α2-AR antagonist idazoxan (3 mg/kg), or vehicle once daily for 14 days. Behavior in the novel object recognition test forced swim test (FST), and locomotor activity test was assessed. ORM-10921 at both doses but not idazoxan significantly reversed immobility in the FST as well as attenuated cognitive deficits in FSL animals.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

α2C-adrenoceptor, AdrenergicReceptor, Adrenergic Receptor, ORM10921, ORM-10921, ORM 10921

Compound Identifiers

PubChem CID

71301276