ORIC-944

SKU: orb2565611

Description

ORIC-944 is a potent, orally bioavailable, and selective PRC2 inhibitor designed for prostate cancer research. It demonstrates antitumor activity in both cellular assays and in vivo models, making it a valuable tool for investigating epigenetic mechanisms in oncology.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2369769-29-7
• MW: 456.52
• Purity: 98.08% (May vary between batches)
• Formula: C₂₆H₂₅FN₆O
• SMILES: N#CC=1N=C2C(=CN=C(NCC=3C(F)=CC=C4OCCC43)N2C1)C5=CC=C(C=C5C)CN(C)C
• Target: Others,Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.23 mM);DMSO:80 mg/mL (175.24 mM)

Bioactivity

• In Vivo:
  Single agent tumor growth inhibition was observed for ORIC-944 in prostate cancer xenograft models. ORIC-944 also improved ARPI antitumor activity in preclinical combination studies and demonstrated in vitro synergy.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ORIC944

Compound Identifiers

PubChem CID

155788096