Org41841

SKU: orb1706867

Description

Org41841 is a dual agonist of the luteinizing hormone/chorionic gonadotropin and thyroid-stimulating hormone receptors, with EC50 values of 0.2 and 7.7 µM, respectively. This small molecule is a valuable research tool for investigating receptor signaling and modeling hyperthyroidism in both cellular and animal studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 301847-37-0
• MW: 402.53
• Purity: 99.92% (May vary between batches)
• Formula: C₁₉H₂₂N₄O₂S₂
• SMILES: COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
• Target: TSH Receptor
• Solubility: DMSO:80 mg/mL (198.74 mM)

Bioactivity

• Target IC50:
  TSHR:7.7 μM（EC50）|LHCGR:0.2 μM （EC50）
• In Vitro:
  org41841 is a partial agonist of TSHR, but its potency is lower than LHCGR.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Org41841, Org-41841, LHCGR, TSH Receptor, TSHR, TSHReceptor, thyrotropin receptor (TSHR)

Compound Identifiers

PubChem CID

9887381