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Org 274178-0

SKU: orb3173194

Description

Org 274178-0 is a selective antagonist of the thyroid-stimulating hormone receptor (TSHR), with a pIC50 value of 5.03 for TSHR. It inhibits the activation of the cAMP and phospholipase C (PLC) signaling pathways mediated by thyroid-stimulating hormone (TSH) and TSH receptor-stimulating immunoglobulins (TSIs). Org 274178-0 shows potential for research in Graves' disease and Graves' ophthalmopathy.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

TargetTSH Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information