Orciprenaline sulfate

SKU: orb1224570

Description

A beta-2 adrenergic agonist used in the treatment of asthma and bronchial spasm.(In Vitro):Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.(In Vivo):Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5874-97-5
• MW: 260.3
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₇NO₃·0·5H₂O₄S
• SMILES: OC1=CC(OS(=O)(O)=O)=CC(C(O)CNC(C)C)=C1
• Target: Adrenergic Receptor
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
• In Vitro:
  Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages. Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to down regulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages. Western blot analysis. Cell line: THP-1 cells and bone marrow macrophages. Concentration: 10 μM. Incubation time: 74 hours. Result: Enhanced β-arrestin2 and its interaction with IκBα. RT-PCR Cell line: THP-1 cells and bone marrow macrophages. Concentration: 10 μM. Incubation time: 74 hours. Result: Led to downregulation of NF-κB.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

dl-Metaproterenol | dl-Orciprenaline

Quick Database Links

Gene Symbol

Adrenergic Receptor