OPN-9643

SKU: orb3174688

Description

OPN-9643 is a covalent inhibitor that targets the central palmitoyl-binding pocket of TEADs, with an IC50 of 15 nM. It prevents auto-palmitoylation and reduces TEAD-driven luciferase activity, as well as classic TEAD target genes such as CTGF and CYR61. OPN-9643 is applicable in cancer research, including studies on melanoma.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2866423-06-3
• MW: 347.34
• Formula: C₁₉H₁₆F₃NO₂
• SMILES: O=C(C=C)N1CC2=CC(OC3=CC=C(C=C3)C(F)(F)F)=CC=C2CC1
• Target: YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

YAP