Opipramol

SKU: orb1688661

Description

Opipramol is a sigma receptor agonist with antidepressant and anxiolytic properties. It has been shown to reduce cocaine-seeking behavior in rodent self-administration models, making it a useful research tool for studying addiction neurobiology and related neurological disorders in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 315-72-0
• MW: 363.5
• Purity: 99.84% (May vary between batches)
• Formula: C₂₃H₂₉N₃O
• SMILES: OCCN1CCN(CC1)CCCN2C=3C=CC=CC3C=CC=4C=CC=CC42
• Target: Sigma receptor
• Solubility: DMSO:80 mg/mL (220.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.08 mM)

Bioactivity

• Target IC50:
  [3H]-dopamine:5.5 μ|sigma recognition site:50 nM (Ki)
• In Vivo:
  Opipramol has been shown to significantly increase dopamine release in vivo by intraperitoneal injection (dose range 5-50 mg/kg).
• In Vitro:
  Opipramol potently binds to the sigma recognition site with a Ki value of 50 nM. Opipramol also inhibits the uptake of [3H] dopamine in crude synaptic preparations with an IC50 value of 5.5 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

G33040, G-33040, Ensidon, Sigmareceptor, Sigma receptor, Sigma Receptor

Compound Identifiers

PubChem CID

9417