Ontunisertib

SKU: orb2944887

Description

Ontunisertib is a potent small molecule inhibitor of TGFβRI/ALK5, demonstrating IC50 values of 100-500 nM for TGFβRI and ≤100 nM for ALK5. It is utilized in research for gastrointestinal diseases, fibrosis, and cancer, with applications in both in vitro cellular assays and in vivo preclinical models.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2647949-48-0
• MW: 469.485
• Formula: C₂₇H₂₁F₂N₅O
• SMILES: O=C(NCC=1C(F)=CC=CC1F)CN2N=C(C=3N=C(C=CC3)C)C(=C2)C=4C=CN=C5C=CC=CC54
• Target: TGF-beta/Smad

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156744887