ONO-7475

SKU: orb1299032

Description

ONO-7475 is a selective small molecule inhibitor targeting the AXL and MER (MERTK) tyrosine kinases. It is a valuable research tool for studying oncogenic signaling in cancer models, demonstrating activity in both in vitro cellular assays and in vivo studies related to leukemia and solid tumors.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1646839-59-9
• MW: 562.57
• Purity: 98.74% (May vary between batches)
• Formula: C₃₂H₂₆N₄O₆
• SMILES: COc1cc2nccc(Oc3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccccc5)c4=O)nc3)c2cc1OC
• Target: Trk receptor,TAM Receptor
• Solubility: DMSO:100 mg/mL (177.76 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (1.78 mM)

Bioactivity

• Target IC50:
  MerTK:1.0 nM (IC50)|Axl:0.7 nM (IC50)
• In Vivo:
  Mice fed a diet containing ONO-7475 exhibited significantly longer survival and, interestingly, blocked leukemia cell infiltration in the liver. In summary, ONO-7475 effectively kills acute myeloid leukemia cells in vitro and in vivo by mechanisms that involve disruption of diverse survival and proliferation pathways.
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• In Vitro:
  ONO-7475 sensitized AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib. In addition, ONO-7475 suppressed the emergence and maintenance of EGFR-TKI-tolerant cells.
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• Cell Research:
  Cell Line:High AXL-expressing cell: PC-9,HCC4011,H1975, PC-9KGR cells. Low AXL-expressing cell: HCC827, HCC4006, and H3255 cells. Concentration:0.0001 μM; 0.001 μM; 0.01 μM; 0.1 μM; 1 μM. Incubation Time:72 hours.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

acute, advanced, Axl, cancer, EGFR, Inhibitor, Mer, leukemia, inhibit, mutunt, lung, metastatic, NSCLC, ONO 7475, ONO7475, ONO-7475, TAMReceptor, TAM Receptor, solid, tolerant, TKI, tumor, Tyro3, Tropomyosin related kinase receptor, Trk receptor, Trk Receptor, Trkreceptor

Compound Identifiers

PubChem CID

90645873