ONO-7300243

SKU: orb1299859

Description

ONO-7300243 is a potent and selective LPA1 receptor antagonist with an IC50 of 0.16 µM. This small molecule is a valuable research tool for investigating the role of LPA1 signaling in fibrosis, neuropathic pain, and cancer metastasis in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 638132-34-0
• MW: 461.55
• Purity: 99.66% (May vary between batches)
• Formula: C₂₈H₃₁NO₅
• SMILES: COc1cc(cc(OC)c1C)C(=O)N(CCCc1ccccc1)Cc1ccc(CC(O)=O)cc1
• Target: LPL Receptor,LPA Receptor
• Solubility: DMSO:100 mg/mL (216.66 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.67 mM)

Bioactivity

• Target IC50:
  LPA1:0.19-0.13 μM (IC50)
• In Vivo:
  The oral administration of ONO-7300243 (17a) to determine its effect on rat IUP. Compound 17a inhibited the LPA-induced IUP increase in a dose-dependent manner (ID50 = 11.6 mg/kg p.o.) up to 1 h after dosing. Significant effects were observed at 10 and 30 mg/kg (p < 0.05 vs vehicle). ONO-7300243 (17a) (30 mg/kg, p.o.) led to a significant decrease in the IUP in conscious rats without LPA stimulation compared with the vehicle without affecting the mean blood pressure (MBP).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, LPLReceptor, LPL Receptor, LPL, LPAReceptor, LPA Receptor, LPA1, inhibit, Lysophospholipid Receptor, ONO 7300243, ONO7300243, ONO-7300243

Compound Identifiers

PubChem CID

66775043