ONO-4059 analog

SKU: orb1300344

Description

ONO-4059 analog

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1351635-67-0
• MW: 456.5
• Purity: 99.25%
• Formula: C₂₅H₂₄N₆O₃
• SMILES: Nc1ncnc2n(C3CCCN(C3)C(=O)C=C)c(=O)n(-c3ccc(Oc4ccccc4)cc3)c12
• Target: Apoptosis,BTK
• Solubility: DMSO:16 mg/mL (35.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.38 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  BTK:23.9 nM
• In Vitro:
  In TMD-8 cells, ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, ONO4059, ONO-4059, ONO4059 analog, ONO-4059 analog, ONO-4059 analogue, ONO 4059, ONO 4059 analog, ONO-WG 307, ONO-WG307, ONO-WG-307, GS-4059 analog, Btk, BTK, Bruton tyrosine kinase, Apoptosis

Compound Identifiers

PubChem CID

121540650