Onjisaponin B

SKU: orb1297531

Description

Onjisaponin B

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 35906-36-6
• MW: 1573.67
• Purity: 99.20%
• Formula: C₇₅H₁₁₂O₃₅
• SMILES: [H][C@@]1(O[C@H]2[C@H](C)O[C@@]([H])(O[C@H]3[C@H](OC(=O)[C@]45CCC(C)(C)C[C@@]4([H])C4=CC[C@]6([H])[C@@]7(C)C[C@H](O)[C@H](O[C@]8([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@](C)(C(O)=O)[C@]7([H])CC[C@@]6(C)[C@]4(CO)CC5)O[C@H](C)[C@H](OC(=O)\C=C\c4ccc(OC)cc4)[C@@H]3O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H](O)[C@@H]2O)OC[C@@H](O[C@]2([H])O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
• Target: Autophagy,mTOR,AMPK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.27 mM);DMSO:50 mg/mL (31.77 mM)

Bioactivity

• In Vitro:
  I the current study, we aimed to identify autophagy inducers from Chinese medicinal herbs as a potential neur Protective agent that enhance the clearance of mutant huntingtin and ± synuclein in PC-12 cells. Through intensive screening usin the green fluorescent protein-light chain 3 (GFP-LC3) autophagy detection platform, we found tha the ethanol extracts of Radix Polygalae (Yuan Zhi) were capable of inducing autophagy. Further investigation showed that among three Single components derived from Radix Polygalae--i.e., polygalacic acid, senegenin and Onjisaponin B--Onjisaponin B was able to induce autophagy and accelerate bot the removal of mutant huntingtin and A53T ± synuclein, which are highly associated with Huntington disease and Parkinson disease, respectively Our study further demonstrated that Onjisaponin B induces autophagy vi the AMPK-mTOR signaling pathwa

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

AMPK, Autophagy, Inhibitor, Onjisaponin B, inhibit, mTOR, PGE

Compound Identifiers

PubChem CID

21669942