ONC212

SKU: orb1299855

Description

ONC212

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1807861-48-8
• MW: 440.46
• Purity: 99.79%
• Formula: C₂₄H₂₃F₃N₄O
• SMILES: FC(F)(F)c1ccc(CN2C3=NCCN3C3=C(CN(Cc4ccccc4)CC3)C2=O)cc1
• Target: GPCR,Apoptosis
• Solubility: DMSO:50 mg/mL (113.52 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.54 mM)

Bioactivity

• In Vivo:
  ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. Based on upregulation of pro-survival IGF1-R in some tumors, Founded an active combination of ONC212 with inhibitor AG1024, including in vivo.
• In Vitro:
  In vitro studies using human acute myeloid leukemia (AML) cell lines, primary AML, and normal bone marrow (BM) samples demonstrate that ONC212 exerts prominent apoptogenic effects in AML, but not in normal BM cells, suggesting potential clinical utility.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ONC 212, ONC212, ONC-212, inhibit, GPR132, Inhibitor, Apoptosis

Compound Identifiers

PubChem CID

124085867