ON044580

SKU: orb2664621

Description

ON044580 is an α-benzoylstyrylbenzyl thioether compound that acts as a non-ATP-competitive JAK2 inhibitor, effective against both wild-type and V617F mutant forms. It suppresses proliferation and induces apoptosis in JAK2V617F-positive and Imatinib-resistant CML cells, and also inhibits BCR-ABL (including T315I mutant), making it a research tool for myeloproliferative neoplasms.

Key Properties

• CAS Number: 1035199-04-2
• MW: 516.34
• Formula: C₂₃H₁₅BrFNO₅S
• SMILES: O=[N+]([O-])C(C=C1/C=C(SCC2=CC=C(C=C2)Br)\C(C3=CC=C(C=C3)C(O)=O)=O)=C(C=C1)F

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

24960018