ON 146040

SKU: orb1309296

Description

ON 146040 is a potent small molecule inhibitor targeting PI3Kα and PI3Kδ isoforms with IC50 values of 14 nM and 20 nM, respectively. This compound is a valuable research tool for investigating PI3K signaling in oncology and immunology, supporting both in vitro biochemical assays and in vivo disease model studies.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1404231-34-0
• MW: 489.55
• Purity: 99.89% (May vary between batches)
• Formula: C₂₄H₂₃N₇O₃S
• SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3NC(=O)\C(Sc3n2)=C\c2ccc(cc2)[N+]([O-])=O)cc1
• Target: PI3K,Bcr-Abl
• Solubility: DMSO:4.9 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  PI3Kδ:20 nM|PI3Kγ:1 μM|PI3Kα:14 nM|Abl-1:150 nM|PI3Kβ:3 μM
• In Vitro:
  ON 146040 inhibits Abl1 and several mutant versions of this kinase with IC50 < 150 nM. ON 146040 is highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1000 nM range. ON 146040 downregulates the phosphorylation of STAT3 and STAT5 in leukemia and myeloma cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Abl1, BcrAbl, ON 146040, ON146040, ON-146040, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, ZINC211117138, ZINC-211117138, ZINC 211117138

Compound Identifiers

PubChem CID

73297262