Omarigliptin

SKU: orb1305710

Description

Omarigliptin

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1226781-44-7
• MW: 398.43
• Purity: 99.77%
• Formula: C₁₇H₂₀F₂N₄O₃S
• SMILES: CS(=O)(=O)n1cc2CN(Cc2n1)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F
• Target: Proteasome,DPP-4
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.02 mM);DMSO:50 mg/mL (125.49 mM)

Bioactivity

• Target IC50:
  DPP4:1.6 nM
• In Vivo:
  METHODS: A diabetic mouse model was established by treating with streptozotocin (STZ). Omarigliptin (2.5, 5 mg/kg, oral) was used to investigat the effects of Omarigliptin on glucose and Insulin levels, cognitive dysfunction, oxidative stress, SIRT3 and FOXO3a expression, and NAD/NADH activity in STZ-induced diabetic mice. Results Omarigliptin can significantly reduce blood glucose in STZ-induced diabetic mice, accompanied by increased serum Insulin levels; Omarigliptin improves cognitive dysfunction in STZ-induced diabetic mice; Omarigliptin treatment rescues GSH in the hippocampus in a dose-dependent manner; Omarigliptin induces increased SIRT3 expression and prevents FOXO3a acetylation.
• In Vitro:
  METHODS: HrGECs cells were stimulated with 0, 1, 2, 10, 20, 100 and 200 μM Omarigliptin for 24 hours and cell viability was observed. Results Whe the concentration of Omarigliptin was 100 and 200 μM the viability of HrGECs cells decreased significantly.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Omarigliptin, orally active, MK3102, MK-3102, MK 3102, inhibit, glucagon like peptide-1, Inhibitor, DPP-4, DPP4, DPP, Dipeptidyl Peptidase, anti-diabetic, anti-parkinsonian, blood-brain barrier

Compound Identifiers

PubChem CID

46209133