Olsalazine disodium

SKU: orb1308244

Description

Olsalazine disodium is a prodrug converted in the colon to the active anti-inflammatory agent 5-aminosalicylic acid (5-ASA). It is used in ulcerative colitis research to study localized drug delivery and 5-ASA's mechanisms in both in vivo models and in vitro assays of inflammation.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6054-98-4
• MW: 346.2
• Purity: 99.52% (May vary between batches)
• Formula: C₁₄H₈N₂Na₂O₆
• SMILES: [Na+].[Na+].Oc1ccc(cc1C([O-])=O)\N=N\c1ccc(O)c(c1)C([O-])=O
• Target: Antibacterial|||COX|||Antibiotic
• Solubility: H2O:38 mg/mL (109.76 mM);DMSO:50 mg/mL (144.43 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Chemotaxis to LTB4 (human intestinal macrophages):0.39 mM
• In Vivo:
  In isolated rat ileal and guinea pig ileal mucosa, Olsalazine (less than 2.89 mM) increases the secretion of sodium and chloride ions, while decreasing the absorption of chloride ions. In isolated rat colonic tissues, Olsalazine (less than 11.5 mM) reduces net sodium levels and chloride ion absorption in a dose-dependent manner, and at high concentrations (11.5 mM), it increases potassium secretion. Moreover, in isolated rat jejunum, Olsalazine inhibits the absorption of glucose and lactose. In human intestinal macrophages (IC50=0.39 mM), Olsalazine acts as an effective inhibitor of the chemotaxis of LTB4.
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• In Vitro:
  In nu/nu CD-1 mice with experimental colitis induced by sodium dextran sulfate, daily treatment with Olsalazine (50 mg/kg) led to the bacterial azoreductase cleavage of azo bonds, releasing mesalazine, which is capable of treating colitis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IFγ, Inhibitor, Olsalazine, Olsalazine disodium, Olsalazine Sodium, inhibit, COX, Dipentum, Bacterial, Antibiotic

Compound Identifiers

PubChem CID

135413505